The New Orleans Saints will be hoping for a home win in Week 1 when they host their NFC South division rival, the Carolina Panthers, on Sunday afternoon. New Orleans was tied for the division lead at 9-8 last season, but lost the tiebreaker to Tampa Bay and missed the playoffs. Carolina was a league-worst 2-15 and is entering a new era under head coach Dave Canales. New Orleans won both meetings last season: 20-17 and 28-6.

Kickoff at the Caesars Superdome is set for 1 p.m. ET. The Saints are 3.5-point favorites in the latest Saints vs. Panthers odds, while the over/under for total points is set at 41.5. The Saints are -196 moneyline favorites, while the Panthers are +163 underdogs. Before making any Saints vs. Panthers picks, you MUST check out the NFL predictions from the SportsLine Projection Model.

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